MHC class-I chain related – MIC

Proteínas MHC e MIC como moléculas de sinal pleiotrópico. 

OJCIUS, D. M.; DELABRE, C.; KOURILSKY, P.; GACHELIN, G.  MHC and MHC-related proteins as pleiotropic signal  molecules  The FASEB Journal, v.16, 202-206, 2002.

 MHC and MHC-related proteins as pleiotropic signal molecules

Palavras chave: interações proteína-proteína, MHC classe I, homeostase.

ABSTRACT

Class I molecules of the major histocompatibility complex (MHC) have been studied primarily for their role in presenting peptide antigens to conventional T lymphocytes. An increasing body of evidence suggests that MHC and newly characterized MHCrelated molecules have a much more varied function in the body. Many of these molecules are involved in pleiotropic interactions with other proteins, which initiate signal transduction cascades and contribute to cellular and tissue homeostasis.